Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis are closely linked to dysfunction of the blood–brain barrier (BBB)—a protective layer that regulates what enters and exits the brain. This review explores how cannabinoids interact with the BBB and the endocannabinoid system, which plays a key role in maintaining brain balance. Researchers highlight that in […]
Research-Based Information
Cannabidiol (CBD) May Reduce Opioid Use While Maintaining Pain Relief in Neuropathic Pain Study (pub. Jan 2026)
Managing chronic neuropathic pain often requires opioid medications, which can carry risks related to dependence and misuse. In this preclinical study, researchers examined whether cannabidiol (CBD) could influence opioid use while preserving pain relief. Using a rat model of neuropathic pain, scientists allowed animals to self-administer the opioid oxycodone, enabling researchers to measure how CBD […]
Cannabinoids Reduces Migraine-Like Symptoms in Preclinical Study (pub. Jan 2026)
Migraines are often linked to increased activity of calcitonin gene-related peptide (CGRP), a signaling molecule known to trigger pain sensitivity, light sensitivity, and other migraine symptoms. In this preclinical study, researchers examined whether a combination of cannabidiol (CBD) and tetrahydrocannabinol (THC) could reduce migraine-like symptoms caused by central CGRP administration in mice. Scientists used established […]