A 2025 scientific review examined how cannabinoids interact with the body and why they are being studied across a wide range of medical conditions. The authors highlighted major cannabinoids including CBD, THC, CBG, CBN, CBC, and CBGVA, noting that these compounds influence the endocannabinoid system as well as other biological pathways involved in pain signaling, inflammation, neurological function, immune regulation, and cellular health. The review describes cannabinoids as multifunctional compounds with potential applications in several areas of modern medicine. (PubMed)

The article discusses evidence suggesting cannabinoids may help manage chronic pain, neurological disorders, cancer-related symptoms, gastrointestinal conditions, stress-related disorders, and inflammatory diseases. Researchers noted that CBD has attracted particular attention because it does not produce the intoxicating effects associated with THC while still demonstrating a broad range of biological activity. The review also explored how cannabinoids may influence neurotransmitter systems, oxidative stress, immune responses, and inflammatory pathways that contribute to disease development and progression. (PubMed)

The authors concluded that cannabinoids show significant therapeutic promise, but emphasized that important challenges remain before these compounds can be widely adopted in clinical medicine. They noted the need for additional human clinical trials to establish standardized formulations, dosing guidelines, long-term safety profiles, and consistent treatment protocols. While cannabinoid research continues to expand, the review highlights the importance of evidence-based development to better understand both the benefits and limitations of cannabinoid-based therapies. (PubMed)

Source: Cannabinoids: Therapeutic Applications, Mechanisms, and Challenges in Modern Medicine. Available at: https://pubmed.ncbi.nlm.nih.gov/42163693/ (PubMed)