Many neurodegenerative diseases—including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and Huntington’s disease—are strongly linked to chronic inflammation within the central nervous system (CNS). This review examines how cannabinoids interact with both the nervous and immune systems and explores their potential role in reducing inflammation that contributes to nerve cell damage. Researchers highlight that cannabinoids can influence multiple biological pathways at once, allowing them to target complex disease processes rather than a single mechanism. (PMC)

The article explains that cannabinoids may help regulate immune signaling in the brain by reducing inflammatory molecule release, calming overactive immune cells, and limiting oxidative stress—factors known to accelerate neurodegeneration. Through interactions with the endocannabinoid system and related receptors, cannabinoids appear capable of supporting neuronal balance while helping protect brain cells from inflammatory injury. These combined actions suggest cannabinoids may contribute to improved neurological stability in experimental models of CNS inflammation and neurodegenerative disease. (PMC)

Overall, the review concludes that cannabinoids show promising anti-inflammatory and neuroprotective potential, making them an area of growing interest in neurological research. However, most current evidence comes from laboratory and preclinical studies, and the authors emphasize that more well-designed human clinical trials are needed to determine safety, optimal dosing, and real-world therapeutic effectiveness. (PMC)

Source

Tomaszewska-Zaremba D, Gajewska A, Misztal T. Anti-Inflammatory Effects of Cannabinoids in Therapy of Neurodegenerative Disorders and Inflammatory Diseases of the CNS (July 2025). National Library of Medicine (NIH): https://pmc.ncbi.nlm.nih.gov/articles/PMC12294762/